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Scientific tests have revealed that knockdown of ULK inhibits autophagosome development. Mice with defects in ULK1 and ULK2 die in 24 h soon after birth [forty one]. When ULK1 is expressed in mammalian cells, ULK2 will not be essential for autophagy. On the other hand, when ULK1 expression is inhibited, ULK2 can compensate to the perform of ULK1 in

Other Option is the appliance of peptidomimetics. They derive from organic peptides and proteins and are acquired by structural modifications utilizing unnatural amino acids, substitution of peptide bond by acceptable surrogates or introduction of conformational restrains.Method for planning in vivo formulation：Just take μL DMSO master liquid, s